Impact of directly observed treatment on tuberculosis

Cultures of sputum, gastric contents, urine, and CSF are positive in most cases.

Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection

In endemic countries, diagnosis and treatment through DOTS of smear-positive cases remains the key to TB control by reducing transmission from infectious cases.

In the prechemotherapy era, it occurred either soon after primary infection in children or young adults or as a terminal event in untreated chronic tuberculosis. The NAAT are not expected to overcome the intrinsic problems related to specimen collection from site of disease and its variable bacillary load.

These patients have higher rates of drug resistance, including single drug resistance, poly drug resistance and MDR—TB 4and therefore require treatment regimens that are guided by DST results.

Tuberculosis of Spine Presentation and Treatment

References[ edit ] This article includes a list of referencesbut its sources remain unclear because it has insufficient inline citations. India leads the world in its burden of tuberculosis TB due to the neglect of TB as a public health problem, and mismanagement of TB patients in both public and private sectors.

However this goal has yet to be realized. JAMA July 7, ; 1: View at Google Scholar T. Tropical Medicine and International Health. Tuberculosis and other conditions[ edit ] Liver disease[ edit ] People with alcoholic liver disease are at an increased risk of tuberculosis.

One study did analyse the relationship between depression and death or treatment discontinuation in people with tuberculosis, 13 but we were unable to identify any study that disaggregated these outcomes.

Directly observed treatment, short-course

Introduction In addition to providing effective treatment and reducing mortality, a primary aim of tuberculosis TB control programs in countries of high TB incidence is to reduce the transmission from infectious TB cases. Protease Inhibitors Rifampin greatly reduces plasma concentrations of PIs and therefore cannot be coadministered safely with PIs given at standard dosages.

The use of directly observed therapy was associated with a decrease in primary drug resistance, acquired drug resistance and relapse in Tarrant County, Texas between and Misdiagnosis and mismanagement can result in only fraction of TB patients getting correct diagnosis, appropriate therapy, and positive outcomes.

Tuberculosis management

The authors with their pooled evidence showing increased risk for TB infection, disease, and deaths commented that their data support a causal link between smoke exposure and an increased chance of acquiring TB, with the primary impact of smoking being to increase the risk of infection [ ].

Re nal tuberculosis may spread to the prostate, seminal vesicles, epididymis, and testis in that order. Under—utilization of sputum microscopy and over—reliance on chest radiography Sputum smear examination is the most reliable way to diagnose patients with pulmonary TB, as it has a high specificity though lower sensitivity, while chest radiographs for the diagnosis of pulmonary TB have higher sensitivity but lower specificity Use of suboptimal diagnostics in the private sector While the private sector underutilizes reliable tools for diagnosis of pulmonary TB, a disturbing trend is the widespread abuse of suboptimal diagnostic tests, such as serological antibody—detection tests for active TB.

Trends in initial drug resistance over three decades in a rural community in south India. Ce ntral Nervous System Tuberculosis Tu berculosis of the central nervous system can present as tuberculous meningitis, tuberculomas, or tuberculous spinal meningitis.


DOTS (Directly Observed Treatment, Short-Course) Directly Observed Therapy (DOT) is the standard of care in many parts of the world for the treatment of TB.

These Migrants are Leading the Fight Against Tuberculosis Worldwide. Tuberculosis is the leading cause of death from a single infectious agent. New infections of TB occur in about 1 per cent of the global population every year.

Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and elimination. The current standard regimen of isoniazid for 9 months is efficacious. Tuberculosis of spine or TB spine or spinal TB was first described by Percivall Pott.

He noted this as a painful kyphotic deformity of the spine associated with then condition is also referred to as Pott’s disease or Pott’s spine. Objective: the objective of this study was to conduct a systematic literature review to assess the impact of directly observed therapy for impact and outcome indicators for tuberculosis.

Method: systematic literature review of observational and experimental studies. The impact of directly-observed treatment on the epidemiology of tuberculosis in Beijing.

Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia

Int J Tuberc Lung Dis ; 4: HT Quy, TN Buu, FG Cobelens, NT Lan, CS Lambregts, MW Borgdorff.

Impact of directly observed treatment on tuberculosis
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Tuberculosis and HIV